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A number of anaerobic bacteria are pathogenic to humans and their virulence is based on secreted toxins, which are mainly produced by species from the Clostridium genus. Particularly, these are not invasive bacteria but their secreted active molecules can exert deleterious effects at a distance from the microorganism. Bolte published a hypothetical paper postulating that a subgroup of children diagnosed with autism could be suffering from Clostridium tetani colonization of the intestinal tract and that the neurological symptoms were the direct result of in vivo production of tetanus neurotoxin.
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