Sex hormone-binding globulin (SHBG) is the primary plasma transport protein for sex steroid hormones. The SHBG gene is located on the short arm of chromosome 17 and the major transcript is encoded by 8 exons, spanning approximately 3.2 Kb. The gene product is a 373 amino acid glycoprotein produced mainly by liver. It regulates the bioavailability of sex steroids to target tissues and its biological half-life is 7 days. Simplistically, as long as bound to SHBG, steroid hormones are inactive and serve as a reservoir for future use. In terms of molecular biology, the multiple interactions between SHBG and its putative receptors in various target tissues (breast, prostate, liver, epididymis) suggest involvement of SHBG in physiology that is more complex than the simple transport of sex steroids in serum.
Citation: Vejrazkova D, Hill M, Vankova M, Lukasova P, Vcelak J, et al. (2013) SHBG Genetic Variability and Glucose Tolerance in T2DM Patients, Gestational Diabetics, and Women with PCOS in Comparison with the Control Czech Population Sample. J Steroids Hormon Sci S12:001. doi: 10.4172/2157-7536.S12-001