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Role of Mcl-1 in ovarian reserve

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Role of Mcl-1 in ovarian reserve

A majority of ovarian follicles are lost to natural death, but the disruption of factors involved in maintenance of the oocyte pool results in a further untimely follicular depletion known as premature ovarian failure. The anti-apoptotic B-cell lymphoma 2 (Bcl-2) family member myeloid cell leukemia-1 (MCL-1) has a pro-survival role in various cell types; however, its contribution to oocyte survival is unconfirmed.

http://www.ncbi.nlm.nih.gov/pubmed/25950485

Courtesy: Omari et al., 2015

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