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The cardiovascular complications of diabetes are mainly responsible for its significant morbidity and mortality and the abundant cost of diabetes to the U.S. healthcare system. The total economic burden of diabetes in 2012 was $245 billion, which was a 41% increase over 2007 estimates. The strain imposed by diabetes could be accelerating rapidly as well. In a study by Boyle et al., assuming the increasing incidence of diabetes imposed by the obesity epidemic continues, the prevalence of diabetes could increase from 14% to a third of the U.S. population by 2050. Globally, the World Health Organization (WHO) estimated there were 217 million people who had diabetes worldwide in 2005. By the year 2030, WHO predicts this number will increase to at least 366 million.
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