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Influence of Non alcoholic Fatty Liver Disease on Heart and it functions
Non-alcoholic fatty liver disease (NAFLD) is one cause of a fatty liver, occurring when fat is deposited (Steatosis) in the liver due to other causes than excessive alcohol use. It encompasses a spectrum of increasingly severe clinicopathological conditions – nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). Fat is deposited in the liver in an amount exceeding 5-10% of its weight. Mortality associated with NAFLD, 10-15 years after its diagnosis, is about 10-12%. Mortality rate is high among NAFLD patients in comparison to the general population is chiefly due to concomitant cardiovascular disease (CVD) than does the progression of the liver disorder [3-6]. The strong association between NAFLD and MS may explain the high cardiovascular mortality observed in NAFLD patients. To analyze the cardiovascular risk, we used the Framingham score. The Framingham risk equation was computed as the probability of developing a coronary event within 10 years, by gender, using the following parameters: age, total cholesterol, HDL-cholesterol, smoking, systolic blood pressure, diastolic blood pressure and diabetes mellitus. The patients were classified into three groups for cardiovascular risk in 10 years as follows: <10% low risk, ≥ 10% and ≤ 20% intermediate risk, and >20% high risk. |
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