The most dangerous form of skin cancer, these cancerous growths develop when unrepaired DNA damage to skin cells (most often caused by ultraviolet radiation from sunshine or tanning beds) triggers mutations (genetic defects) that lead the skin cells to multiply rapidly and form malignant tumors. Melanoma is the major skin cancer type which affects in larger population and highly risk mediated. Several molecular mechanisms appear to play a major role in melanoma genesis and progression. Current targeted therapies focus on contrasting the activation of RAS/RAF/MEK/ERK and to a less extent, PI3K/AKT pathways. Even if you have carefully practiced sun safety all summer, it's important to continue being vigilant about your skin in fall, winter, and beyond. Throughout the year, you should examine your skin head to toe once a month, looking for any suspicious lesions. Surgical excision, Mohs micrographic surgery are the better treatments available in preferred treatments in curing Melanoma.