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Vitamin D deficiency is common in Western populations, especially in the elderly population . Hypovitaminosis D peaks in the spring when vitamin D serum levels are at its lowest because of negligible skin synthesis of vitamin D caused by low levels of ultraviolet B radiation . While the repercussion of vitamin D deficiency on bone health is well understood, the impact of vitamin D deficiency on mental health, particularly on depression, remains unclear. The aim of this editorial is to highlight the major studies that examined the correlation between vitamin D deficiency and depression attempting to determine whether vitamin D supplementation is promising in prevention and/or treatment of depression.