Non-Alcoholic Fatty Liver Disease (NAFLD) is a growing health problem, and may progress to liver cirrhosis and hepatocellular carcinoma after the formation of steatohepatitis. Much evidence suggests that NAFLD is highly prevalent in obese populations. For instance, the prevalence of NAFLD increases from 10 to 24 percent of the general population to 57.5 to 74 percent of the obese population . Because of this, the interaction between fat deposition and insulin resistance, two critical aspects commonly associated with obesity, appears to underlie the development of NAFLD and the progression of steatohepatitis. Beyond common sense, recent evidence also supports the involvement of new mechanisms in the pathogenesis of NAFLD, as well as steatohepatitis.
Wu C (2012) Interactions among Hepatic Steatosis, Inflammation, and Insulin Resistance: Beyond Common Sense. J Nutr Food Sci 2:e106. doi: 10.4172/2155-9600.1000e106