A rapidly advancing nanotechnology is focusing on producing better, efficient, and safer molecules to be used for several biomedical and diagnostic applications. Hybrid nanomaterials have been produced encompassing a plethora of applications in the areas of medicine and therapeutics. These new generation materials are proving to be much better than their earlier counterparts because of their excellent biomimetic properties, which are reflected in their healthy interactions with cells and tissues. However, without a comprehensive assessment of their properties and associated effects, these cannot be marked as completely safe. In this context, it becomes relevant to realize their cytocompatibility, adverse effects, and experimental evaluation by in vivo and in vitro testing. So here, we have tried to provide a brief and comprehensive review highlighting biosafety and/or biocompatibility features of nanocomposites and nanoceramics.