Land application of treated wastewater is increasing particularly in areas where water stress is a major concern. The primary objective of this study was to quantify the effect of irrigation with aerated lagoon treated wastewater on soil properties. Core and bulk soil samples were collected from areas under the canopies of mesquite and creosote and intercanopy areas from each of the three plots. Irrigation water quality from 2006 to 2008 showed that average sodium adsorption ratio (SAR), electrical conductivity (EC) and pH of irrigation water were 37.16, 5.32 dS m-1 and 9.7, respectively. The sprinkler uniformity coefficients of irrigated plot-I was 49.34 ± 2.23 % and irrigated plot-II was 61.57 ± 2.11 %. Within irrigated and between irrigated and un-irrigated plots, most soil physical properties remained similar except saturated hydraulic conductivity (Ks) which was significantly higher under mesquite canopies than in the intercanopy areas.