alexa Mechanisms of Antibiotic Resistance

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Mechanisms of Antibiotic Resistance

Antimicrobial resistance (AMR) is when microbes are resistant to one or more antimicrobial agents used to treat infection or as an antiseptic. Resistance is either innate or acquired – referring to whether the resistance is newly developed or has always been present in an organism.

Mechanisms of Antibiotic Resistance

  • The inactivation or modification of the antibiotic;
  • An alteration in the target site of the antibiotic that reduces its binding capacity;
  • The modification of metabolic pathways to circumvent the antibiotic effect;
  • The reduced intracellular antibiotic accumulation by decreasing permeability and/or increasing active efflux of the antibiotic.

As resistance to antibiotics becomes more common, a greater need for alternative treatments arises. 

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