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Transplantation of bone marrow-derived mesenchymal stem cells (MSCs) is a promising therapy for spinal cord
repair. Its potential, however, is limited by poor survival of the cells in the damaged nervous tissue. A number of studies have tried to improve MSC transplant survival, yet often with limited or short-term effects. Survival enhancing strategies include optimizing timing of transplantation, suppressing the immune response, transplantation within a scaffold to limit anoikis, reducing reactive oxygen species and/or macrophages,