alexa Deletion 13q14 in Plasma Cells of a Patient with Lupus Erythematosus and Autoimmune Hepatitis

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Deletion 13q14 in Plasma Cells of a Patient with Lupus Erythematosus and Autoimmune Hepatitis

The molecular mechanisms that lead to autoantibody production and autoimmune disease remain poorly defined. Based on a clinical observation in a patient with lupus erythematosus and autoimmune hepatitis we here provide the first evidence that (i) a particular cytogenetic aberration (deletion (13)(q14)) could be detected in a proportion of plasma cells and that (ii) the surface marker CD56 could be used to enrich for plasma cells with this cytogenetic aberration.

itation: Tuve S, Sommer U, Kostka H, Mohr B, Oelschlägel U, et al. (2014) Deletion 13q14 in Plasma Cells of a Patient with Lupus Erythematosus and Autoimmune Hepatitis. J Bone Marrow Res 2:147.

 
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