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Hepatic veno-occlusive disease (VOD) -also known as sinusoidal obstruction syndrome- is considered one of the leading causes of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). Pathophysiology is thought to be multifactorial: endothelial injury in both sinusoids and small hepatic venules leading to subendothelial deposition of platelet and coagulative material, which results in centrilobular necrosis and post-sinusoidal obstruction ]. Defibrotide is a mixture of porcine oligodeoxyribonucleotides that has antithrombotic, anti-ischemic and anti-inflammatory properties.
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