Alcoholic Liver Disease (ALD) is still a major problem in Western and Asian countries. The long-term impact of ALD might further lead to liver disease complications, such as liver cirrhosis and liver cancer. The safe limit amount of alcohol might be different between Western and Asian countries as the genetic factor might also become an important role in the liver disease progression. It is well-known that alcohol consumption would have synergistic liver injury effect together with chronic viral hepatitis infection. However, in non-alcoholic fatty liver disease (NAFLD), mild to moderate alcohol consumption might have a beneficial effect as it might protect the liver.