Celiac Disease

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Celiac Disease

Meta Description: Celiac disease is a protein malabsorption syndrome and generally results from intestinal sensitivity to the gliadin fraction of glutens from rye, wheat, oats and barley. The association between intestinal T-cell Non-Hodgkin lymphoma and celiac disease called enteropathy associated Tcell lymphoma, which appears to be particularly strong but these lymphomas are very rare.

Celiac disease is a protein malabsorption syndrome with systemic manifestations. It generally results from intestinal sensitivity to the gliadin fraction of glutens from rye, wheat, oats and barley. Most of the children present at the age of two, but severity of the disease varies from age to age. It is thought that villous atrophy and intestinal damage results from a cell mediated immune response which was generally initiated by exposure to a gliadin polypeptide fragment.

The increased situation of celiac disease in children with IgA deficiency, type 1 diabetes mellitus and down syndrome is consistent with possible immunologic factors in developing celiac disease. Individuals with DR4 and DR3 tissue types are at higher risk. The association of celiac disease and intestinal lymphoma is well known. The association between intestinal T-cell Non-Hodgkin lymphoma and celiac disease called enteropathy associated Tcell lymphoma, which appears to be particularly strong but these lymphomas are very rare.

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