alexa Cardiac Troponins and their role in Heart Diseases

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Cardiac Troponins and their role in Heart Diseases

Cardiac troponin T and troponin I are cardiac regulatory proteins that control the calcium mediated interaction between actin and myosin. Troponin is a complex of three regulatory proteins (troponin C, troponin I, and troponin T) that is integral tomuscle contraction in skeletal muscle and cardiac muscle, but not smooth muscle. the use of troponin in the setting of cardiac emergencies has spread the gold standard for the diagnosis of acute coronary syndromes. The use of these markers in patients with chronic kidney disease may imply a decrease in their specificity unless we establish an appropriate cut-off according to glomerular filtration rate. Troponin is a protein released from myocytes when irreversible myocardial damage occurs. It is highly specific to cardiac tissue and accurately diagnoses myocardial infarction with a history of ischaemic pain or ECG changes reflecting ischaemia. Cardiac troponin level is dependent on infarct size, thus providing an indicator for the prognosis following an infarction

 
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