A great deal of excitement has been created in the area of stem cells, with the hope that many currently incurable diseases may in time become curable. Both embryonic and adult stem cells research has recently produced successful results, which may become subjects for drug discovery and disease diagnosis. In spite of significant progress in the early detection and treatment of this malignant disease, “cancer” currently available therapeutic regimens are constrained in their ability to completely eradicate tumors or to prevent recurrence and progression to metastasis.
Tumors and distant metastasis often recur, even after completion of therapy. Moreover, existing therapies are relatively nonspecific and highly toxic, often killing normally proliferating cells as well as tumor cells.
Therefore new cellular and mechanistic insights are needed to decipher why current preventive and therapeutic interventions have limited efficacy, and why tumor metastasis recurs.
View more at: Cancer biology and Therapeutics