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Recent data suggest that the weight loss-associated increase in the osteoblast-specific peptide osteocalcin (OC) might be related, not to increased bone formation, but to the endocrine action of OC enhance to both pancreatic insulin secretion and insulin sensitivity of target tissues. Thus, the purpose of the present study was to examine the possible role of serum OC as a regulator of glucose homeostasis following weight loss in sedentary overweight or obese women.
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