Based on increased life expectancy, it is estimated that there will be over 1.2 billion older adults (over 60 years old) worldwide in 2025. Older adults are more susceptible to different clinical conditions, such as tumors, neurodegenerative diseases and cardiovascular diseases. This is at least partially attributed to an age related increase in frailty and immunosenescence, and perhaps mitochondrial dysfunction. Maintenance of physical function in older adults is therefore a major public and clinical priority. In this regard the application of small natural compounds is a promising avenue of therapeutical intervention.
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