Indrayava (Holarrhena antidysenterica seed) has been used in bleeding piles, diarrhea, eczema, fever and colic as per Ayurveda. The folklore use of Indrayava for curing diabetes is reported as taking10 grams of Indrayava soaked overnight in 80 ml of water and then drinking the liquid. The Pharmacological study for anti-diabetic activities and acute toxicological studies of the Indrayava are well documented and LD50 is greater than 3000 mg/kg body weight. We are presenting a case of newly diagnosed diabetes with severe hyperglycemia (Post Prandial blood sugar >500 mg/dl), administrated 10 gm of Indrayava soaked overnight in 80ml water and advised to take water for a period of 48 days in I.P.D. The primary treatment outcomes were reduction of fasting and post prandial blood sugar with glycosylated hemoglobin. There was a reduction of elevated triglyceride level with marked clinical improvement also. There was no change in the pre and post treatment biochemical and hematological safety profile of the patient. Our case study opens a modality of treatment in uncomplicated severe hyperglycemic patients. Further randomized control clinical trial is suggested.