Nanosized materials are extensively used in design of the optical devices, catalysts, biosensors, imaging agent, drugs and gene delivery, etc. There are a large number of nanoparticles including gold nanoparticles, polymeric nanoparticles, quantum dots, bioceramic based nanoparticles and so on that are applied as carriers in the drug delivery systems. Definitely, dominant physicochemical properties of these materials such as small size and high surface to volume ratio lead to improvement of their effectiveness as a suitable carrier in drug and gene delivery.