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Polyethyleneglycol (PEG) has often been used to extend the circulation time of liposomes. PEG is a highly hydrophilic polymer with very low toxicity. PEG and its derivatives have been widely used to improve the stability and pharmacokinetics characteristics of drug carriers. A worth mentioning example is the doxorubicin-loaded PEGylated liposomes (Doxil®) which have a potent, yet low toxic, pharmacological effect.
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