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The superior vena cava syndrome (SVCS) was defined in a review in terms of when “Patients with superior vena cava obstruction present complaining of face, neck, and arm swelling; shortness of breath; orthopnea; and cough.” Concerning its historical angle, that review only mentioned that William Hunter described the first patient with the syndrome in 1757. This historic date was accepted by Ahmann. However, concerning lung cancer, Davies did warn, as far back as 1835, in terms “of their greater rarity, of their signs being scarcely known, and their mode of treatment being very imperfectly understood.”
The Superior Vena Cava Syndrome: History and the Present Prospects of Target Therapy