Beta-blockers are a class of drugs used to control symptoms of heart failure that are made worse by certain hormones called catecholamines. The body releases these hormones as part of its response to heart failure. Cardiovascular diseases (CVD) represent the major health problem in the western world and heavy social and economic burden. Heterogenous group of multifactorial conditions is included and there is appreciable inter-individual variability in the susceptibility to cardiovascular disease and in the response to the associated pharmacological treatments. Beta-blockers can slow the progression of systolic forms of heart failure. Beta-blockers may be used to treat left ventricular systolic dysfunction in people who are stable and have no symptoms or only mild to moderate heart failure symptoms.