Hypertensive Cardiovascular Renal Disease (HCVRD) procession can be viewed as an disorder of growth and development in higher animals - a non-tumorous proliferative disorder. A greater incidence of most cancers in populations with hypertension has been very well noted.
Peptide Growth Factor (PGF’s) usually are potent regulators of cell growth from unicellular to complex multicellular organisms. Through a combination of autocrine, paracrine, and endocrine modes of action, PGF’s control the activity of all other growth modulators including classical hormones, such as the Renin-Angiotensin-Aldosterone (RAA) system, which they predate on the evolutionary scale.
Epidermal growth factor (EGF) and its epidermal growth factor receptor (EGFR), when present, dominate this control through a process of extensive cross talk and transactivation.
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