alexa Vasculogenic Mimicry in Merkel Cell Carcinoma

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Vasculogenic Mimicry in Merkel Cell Carcinoma

Nowadays there is enough evidence that tumors acquire microcirculation not only by angiogenesis. The concept of Vasculogenic Mimicry (VM) by melanoma cells was introduced in 1999 by Maniotis and is the ability of aggressive melanoma cells to form Extracellular Matrix (ECM)-rich vasculogenic-like networks. One form of VM is a histological pattern in tumors detected by Periodic Acid Schiff (PAS)-staining (PAS loops). Another form of VM refers to cancer cells directly lining tumor spaces or channels, which contain erythrocytes (blood lakes). Both forms are a result of dedifferentiation by aggressive melanoma cells adapting an embryonic-like phenotype. Since the first description of Vasculogenic Mimicry (VM) this concept is found in other aggressive tumor.
 

Citation: van Beurden A, van Dijk CM, Baeten CIM (2014) Vasculogenic Mimicry in Merkel Cell Carcinoma. J Cytol Histol 5:241.

 
  • Share this page
  • Facebook
  • Twitter
  • LinkedIn
  • Google+
  • Pinterest
  • Blogger
 
adwords