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Background: Insulin resistance is recognized as impairment subjacent in many metabolic disorders, most of them conditioning the development of diabetes mellitus type II. Cut-off points for clinical parameters such as glucose or HDL cholesterol have been established; however there is no consensus for cut-off points for two of the most used parameters to detect insulin resistance: insulin and homeostasis model assessment of insulin resistance (HOMA-IR). The aim of this study is to propose cut-off points for normal blood levels of insulin and HOMA-IR for young Mexicans. Methods: A sample of 1,359 young Mexicans (17-24 years old) was studied.