Alzheimer’s disease, the most frequent form of dementia that accounts for 50-70% of all cases, impairs memory and learning, precludes independent living, and poses psychological and financial strain on caregivers and the healthcare system. Since the first discovery from a patient of Alois Alzheimerin 1906, a century of vigorous research has established key pathological features, including the conspicuous neuro degeneration that preferentially target shippo campus and the deposition of cerebral amyloid plaques and neurofibrillary tangles. However, there have been no established strategies to treat Alzheimer’s disease, and the currently-identified risk factors for Alzheimer’s disease (i.e., aging and ApoEɛ4 allele) are non-modifiable. As a large number of baby boomers will be facing elevated risks of developing Alzheimer’s disease in the near future, there is an ever increasing need to search for modifiable risk factors and to identify intervention strategies to attenuate and prevent the disease development . Emerging evidence indicates that vascular dysfunction and risk factors for vascular disease may be mechanistically linked with an elevated risk of dementia and that regular physical activity may improve cognitive function presumably through the improvement of vascular function.
Citation: Tarumi T, Tanaka H (2012) Alzheimer’s Disease and Habitual Exercise: Relationship Mediated and Fostered by Vascular Risk Profiles? J Gerontol Geriatric Res 1:e111. doi: 10.4172/2167-7182.1000e111