alexa Novel Strategies in the Treatment of Multiple Myeloma

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Novel Strategies in the Treatment of Multiple Myeloma

The proteasome serves as the catalytic core of the Ubiquitin (Ub) protein degradation pathway and has become an intriguing target in drug development and cancer therapy. Successful pharmacologic inhibition of the proteasome with the small molecule bortezomib led to US Food and Drug Administration (FDA) regulatory approval for the treatment of mantle cell lymphoma and multiple myeloma (MM) and has been extended to a steadily increasing number of clinical trials to assess effi cacy and safety in other hematologic malignances and solid tumors.

 

Citation:

Driscoll JJ, Burris J, Annunziata CM (2010) Novel Strategies in the Treatment of Multiple Myeloma: From Proteasome Inhibitors to Immunotherapy. J Cell Sci Ther 1:101.
 
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