Detection of early skin cancer is done by a medical procedure named biopsy, which involves the removal of tissues from a living object. The removed tissue is processed by an extensive preparation procedure which includes fixing, embedding, sectioning, staining and placed under a microscope for pathologist examination. Errors may occur during tissue processing and it leads to in accurate diagnosis. It is painful, side effects may also occur like infection and spreading of cancer cells. Optical virtual biopsy techniques for cells and tissues imaging provides capable microscopic details about the benign and malignant lesions without tissue removal. This non-invasive in vivo virtual biopsy avoids or minimizes the above mentioned disadvantages involved in virtual biopsy procedure. It also reduces the cost and time consumption in traditional biopsy procedures.

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