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Cholera is an infection of the small intestine. It is one of the world’s oldest diseases and it is caused by the bacterium Vibrio cholera which is a Gram-negative, facultative anaerobic, comma-shaped bacterium. The basis of the infection is through V. cholerae secreting choleragen also known as “the cholera toxin”. Structurally, the toxin is similar to heat-labile enterotoxins associated with enteric bacteria, majorly two serogroups of V. cholerae termed O1 and O139 cause outbreaks.
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