The persistence, spread and escalation of Ebola virus disease (EVD) ravaging West Africa is now a serious global threat. The epidemic has resulted in unprecedented number of deaths and cases including health care workers in countries with the poorest staffing patterns. This article provide a general background information on EVD and specifically address what is known and what need to be done at individual and society level to mitigate its effect. The epidemic appears to be attributed and sustained by negative socio-economic factors, notably extreme poverty, poor health infrastructure and disintegrated health care system. The extreme social-economic factors have created an atmosphere of fear, panic, helplessness, hopelessness further perpetuating the epidemic. There is need for the international community to scale up support for the affected countries to mitigate stress, restore supplies, economic activities and instill hope. Global concerted efforts, resource mobilization and support will contain and slow down the outbreak preventing international disaster and globalization of the outbreak.