The assessment of MMR molecule expression is well-accepted for identification of Hereditary Non-Polyposis part Cancer (HNPCC) -associated cancers (i.e.), cancers of the colorectum, mucosa, stomach, ovaries, tract, totally different gi sites and brain). In fact, loss of MMR molecule expression may facilitate to identify those with germline MMR sequence mutations, which in turn may offer individuals with an opportunity for cancer bar through part, mucosa and endocrine gland cancer risk management decisions as written inside the NCCN pointers. In addition, it provides at-risk relatives the possibility to forestall cancers through increased cancer screening and/or prophylactic surgeries. Furthermore, MMR deficiency has the potential to identify a particular pathway to tumorigenesis, which will have implications to designation and treatment.