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AMPK: AMP-Activated Protein Kinase; AICAR: 5-Amino-1-Beta- D-Ribofuranosyl-Imidazole-4-Carboxamide; BDNF: Brain Derived Neurotrophic Factor; COPD: Chronic Obstructive Pulmonary Disease; GW1516: {4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5- yl}methyl)sulfanyl]-2-methylphenoxy}acetic acid; IGFs: Insulin-Like Growth Factors; PGC-1α: Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-α; Ppars: Peroxisome Proliferator-Activated Receptors. Skeletal muscle has long been known as the target of several growth factors and hormones, including IGFs, steroids, thyroid and neurohypophyseal hormones, often regulating both muscle development and homeostasis in postnatal life, as summarized in classical as well as more recent reviews. Such a complex hormonal regulation is not surprising, if one considers the many diverse functions muscle exerts: mechanical force production, body temperature regulation and metabolic storage due to its protein content. Active muscle accounts for over 90% of total body energy expenditure.
Citation: Coletti D, Adamo S (2015) Will exercise mimetics hold promise? J Pharmacovigilance 3:e138.
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