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This is a paper which examines the causes, symptoms, predisposing factors, prevention, and control of neonatal tetanus in African children. Neonatal tetanus was found to be the leading cause of death among neonates. It was found to result mainly from social and environmental factors, such as poor hygiene, use of non-sterile materials in treating the stump of umbilical cords in newborns, poor attendance to antenatal clinic, high-level illiteracy, and non-utilization of tetanus toxoid immunization.