alexa Polymyalgia Rheumatica and its Association with Cancer

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Polymyalgia Rheumatica and its Association with Cancer

Author(s): Emily C Pfeifer, Cynthia S Crowson, Brittny T Major and Eric L Matteson

Polymyalgia rheumatic (PMR) is a common inflammatory condition, with a female predominance, diagnosed most in the elderly, with an estimated incidence of 58.7 per 100,000 persons over the age of 50 years. The incidence of PMR increases with age, and as the population continues to mature in coming years these numbers areexpected to grow. The etiology of PMR is currently unknown and can often be difficult to distinguish from other inflammatory conditions, including rheumatoid arthritis,  spondyloarthropathies, or metabolic and malignant disorders. Some of these autoimmune disorders, including rheumatoid arthritis and systemic lupus erythematosus, have been found to be associated with certain forms of cancer. In contrast, patients diagnosed with giant cell arteritis (GCA), a condition associated with PMR, have been found to have fewer malignancies prior to diagnosis of GCA when compared to controls, and certainly no increased risk for cancer.

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