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Pi3k Pathway-Specific Inhibitors: New Hope for Patients with Er-Positive or Her2-Positive Breast Cancers
The De’s laboratory seeks to investigate tumor suppressor and oncogene signaling pathways that are altered in breast tumors using a multidisciplinary approach that includes genetics, biochemistry, bioinformatics, and pathology. As a signal transduction research laboratory, we would like to understand how to phosphorylation and dephosphorylation of cellular proteins results in regulated and coordinated signal relay in ER+ and HER2+ breast cancers include all of the intrinsic molecular subtype. Furthermore, we are interested how the different oncogenic signaling pathways interact to dysregulate cell signaling (otherwise in fine tuned) in the context of genetic influences or when other membrane receptor tyrosine kinases are activated at the same time. READ MORE
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