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The clinical management of patients with liver diseases as most liver diseases remain poorly diagnosed, staged and treated. Translational Research developing for diagnostic biomarkers, predictors of disease progression or new therapeutic targets is needed for all forms of liver injury from chronic viral infection, to liver fibrosis, steatosis, cirrhosis and cancer. The development of new therapeutic agents is critical for further improvement in the management of chronic hepatitis C, as current therapies have low efficacy in certain patient subgroups and are associated with frequent side effects affecting the patient’s quality of life. Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disorders ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Steatosis has been described as histological changes within the liver and commonly exists in patients who remain asymptomatic.