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Aptamers are short single-stranded nucleic acid oligomers (ssDNA or RNA) that can form specific and complex three-dimensional structures which can bind with high affinity to specific targets, including cancer cells. The term ‘aptamer’ is derived from the Latin word aptus meaning “to fit” [7]. A procedure to derive sequences recognizing specific targets was first described under the name of Systematic Evolution of Ligands by Exponential Enrichment (SELEX). The method enables isolating an aptamer of interest from a pool of randomized molecules by repeated steps of incubation with the target, partitioning and amplification, until the pool of molecules becomes enriched in a particular clone [8].
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