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Cholera is an acute watery diarrheal disease caused by Vibrio cholerae (V. cholerae). The emergence of a new serogroup of V. cholerae O139 during early 1990s showed no cross-protection with serogroup O1, but remained confined to Bangladesh, India and other Asian countries. Some cases were reported from developed countries, mostly among travelers. The global burden of cholera is huge, particularly in developing countries. Every year an estimated 2.8 million cases of cholera and about 91,000 deaths occur in endemic countries
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