alexa Recombinant Vaccine

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Recombinant Vaccine

Scrub typhus is caused by the infection of Orientia tsutsugamushi, an obligate intracellular Gram-negative bacterium . The disease is characterized by fever, rash, eschar, pneumonitis, meningitis, and in some cases, disseminated intravascular coagulation that may lead to circulatory failure. It accounts for up to 23% of all febrile episodes in endemic areas of the Asia-Pacific, while recent estimations in Thailand are about 20%. Scrub typhus can be fatal if left untreated and reports from India have documented 12-17% fatality rates. Geographic distribution of the disease occurs within an area of about 13 million square kilometers and includes Pakistan, India and Nepal in the West to Japan in the East, and from South eastern Siberia, China, and Korea in the North to Indonesia, Philippines, Northern Australia and the intervening Pacific islands in the South.

 
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