Amyloidosis is a disorder that occurs due to abnormal build-up of proteins in tissues and organs. The cause for primary amyloidosis is not known till now. This condition is related to production of antibodies excessively and abnormally by plasma cells, a type of immune cell. Abnormal proteins build up as clumps in certain organs and results in reduction in their ability to work properly. Symptoms of this disease depend on the organs affected. This disease can affect tongue, intestines, smooth and skeletal muscles, nerves, spleen, skin, ligaments, heart, liver and kidneys. Symptoms include shortness of breath, abnormal heart rhythm, fatigue, numbness of hands, numbness of feet, hoarseness or changing voice, and joint pain.