alexa MAPK Alterations in Pediatric Gliomas

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MAPK Alterations in Pediatric Gliomas

Although the mitogen-activated protein kinase (MAPK) pathway helps promote normal cell development, the pathway is known to contribute to the initiation and growth of many types of cancers. Tumorigenesis can result from mutations in a number of the pathway’s key proteins, including but not limited to RAS, any one of the three RAF kinases, or MEK1/2. Moreover, by discovering and understanding the biology of oncogenic mutations, scientists can develop novel targeted therapies.


Citation: Truong AY, Nicolaides TP (2015) Targeted Therapy for MAPK Alterations in Pediatric Gliomas Brain Disord Ther S2:005.

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