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Initial characterization of the epidemiology of perinatal depression in Ghana coupled with the potential adverse effects on child survival and the health of the mother, is a call for immediate action. These children and mothers have to be helped using innovative strategies if necessary but without having to re-invent the wheel! Various interventions to tackle perinatal depression have evolved over the years, and evidence appears to be converging on preventive and curative measures using lay community resources particularly in settings with inadequate mental health infrastructure.