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Lynch syndrome (LS), eponymous for hereditary non-polyposis colorectal cancer (HNPCC), is the most common form of hereditary colorectal cancer (CRC). LS are caused by germline mutations in one of four DNA MMR genes (MMR), MLH1, MSH2, PMS2 and MSH6. These DNA MMR genes maintain genomic stability by correcting nucleotide mismatches that occur during DNA replication.
Citation: Baichoo E, Boardman LA (2013) Genetics of Young Onset Colorectal Cancer. Hereditary Genet 3:124.
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