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Adenosine deaminase (ADA) is a purine-degrading enzyme that catalyzes the deamination of adenosine in an irreversible manner, which results in the production of inosine. Adenosine deaminase levels can be rapidly measured in various body fluids, and they might provide an alternative for the diagnosis of tuberculosis. Several studies reported the use of ADA in the diagnosis of TB in other fluids including meningeal, pleural, and pericardial effusions, suggesting that increasing ADA activity relates to the intensity of stimulation and the maturation state of the lymphocyte, due to the immune cellular response against Mycobacterium tuberculosis.
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