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Infections caused by NTM are a diagnostic as well as therapeutic dilemma. All the bacterial and fungal culture-negative skin lesions not responding to conventional interventional strategies need to be investigated for evidence of tubercular and non-tubercular mycobacterial causes. Role of microscopy in diagnosis and management of tuberculosis can’t be under played but species identification appears to be absolutely essential component in the management of NTM infections since antimicrobial sensitivity and therapies differ significantly depending on the species isolated