Tuberculosis (TB) is still a leading cause of death in humans and therefore remains a global health problem. Mycobacterium tuberculosis (MTB) infects approximately one-third of the human population. In 2013, there were an estimated 9.0 million cases and 1.5 million deaths. Among people with pulmonary TB (PTB), those from South-East Asia, Western Pacific and African regions account for three quarters. Spain is one of the European countries with the highest rates of incidence and prevalence of TB. Approximately, 10% of individuals infected with MTB develop active pulmonary disease, suggesting that there exist differences in susceptibility or resistance to progression.