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Heterogeneity of p53 inactivation in human cancer. 1- p53 mutations can be found in 50% of human cancers, but their penetrance is highly heterogeneous, as reflected by the diverse remaining transactivation activity that ranges from O to 100%. 2- Various DNA viruses, such as SV40, HPV or adenoviruses, encode proteins that target p53 protein. 3- In inflammatory breast cancer and neuroblastoma, p53 is predominantly found in the cytoplasm. 4- mdm2 accumulation is found in numerous cancers, such as sarcoma or breast carcinomas. 5- PTEN, a p53 regulated gene, is mutated in various types of cancer including glioblastoma.
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